Full Mojo Rampage's roguelike nature means that each time you start the game, you will find yourself facing newly configured levels, and while your mission in each level is primarily driven by the quest you chose to work through, just because the objective is the same from play-to-play, doesn't mean that some of the generated maps won't be harder than others.
The game contains four main quests, and it is the levels in these quests that will unlock various features in Full Mojo Rampage. Primarily these are various stat or attack modifiers for your character, but, when you've completed a quest, the reward can also be a new quest or gameplay mode to try out.
Before starting a quest, you will get the option to customize your character in different ways. You can choose between different masks, voodoo pins or voodoo Loa (gods). While the masks are just for looks, the pins give different stat boosts and the Loa you choose changes the attacks your character has available to it. As you unlock more options, you will be able to find combinations of these elements that should fit your gameplay style, but making progress in Full Mojo Rampage isn't easy - more on that later.
The levels themselves are filled with various enemies, each with their own tasks designed to keep you from completing your quest, and they come in many shapes and sizes. You will often find the bigger enemies with larger health bars near your objectives, while smaller ones are much more frequent and do a good job of swarming you. Levels also contain a plethora of items for your character to pick up and either gain stat boosts while equipped, or provide attacks that are more powerful than your standard, but with limited ammo.
Outside of the four main quests, Full Mojo Rampage also features a mode called Night of the Dead Spirits. Here you will need to survive a set number of enemy waves in a claustrophobic arena. Once you've beaten that, Survival Unlimited unlocks, which is similar to the previous option, but without the wave-cap. This game also features an Endless Run Mode. Here you will play through dungeon after dungeon. Between these levels everything from the type of dungeon to bonuses or drawbacks can change, but even without these changes, this mode is designed to make each level harder than the last.
Full Mojo Rampage also features a Daily Quest option. Each day, a dungeon is generated and everyone can try their hand at it. The benefit to this mode, besides earning experience and money, is bragging rights as the game lets everyone know who the previous day's winner is all day long.